As comprehensive genomic profiling (CGP) becomes central to precision oncology, clinical laboratories face mounting pressure to manage the complexity and volume of NGS data for solid tumors. Manual variant interpretation creates bottlenecks in scalability, consistency, and turnaround time — particularly in high-complexity reference center settings. In "From Bottleneck to Scale: Modernizing Solid Tumor NGS Interpretation," Nenad Kunac, MD, PhD (University Hospital of Split) and Daiana Ganiewich (SeqOne) share how their team transitioned to a centralized, case-centric bioinformatics platform and validated it for routine clinical use.
What You'll Learn:
- Unified Workflow: How SNVs, indels, fusions, MSI, and TMB can be interpreted within a single standardized platform — eliminating fragmented tooling and manual reconciliation.
- Validation Strategy: The approach used to assess concordance, reproducibility, and clinical reliability under real-world routine conditions.
- Real-World Scaling: Practical lessons from implementation at a high-complexity university hospital, including workflow design decisions and challenges encountered along the way.
Meet the Speakers:
- Nenad Kunac, MD, PhD — Head of Molecular Pathology at the University Hospital of Split, leading solid tumor NGS interpretation in a high-volume public reference center.
- Daiana Ganiewich — Director of Product Management, Oncology at SeqOne.
